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目的 :探讨肾移植受者术后早期环孢素服药后 2h全血浓度 (C2 )监测的临床意义。方法 :用特异性荧光偏振免疫法(FPIA)同步测定 5 8例肾移植受者 6 6 7对全血谷浓度C0 与C2 浓度 ,回顾性分析C0 、C2 监测在预测肾移植急排反应和不良反应中的有效性。结果 :环孢素的C2 推荐范围为 :术后≤ 1月为 110 3～ 16 4 6ng·ml-1;术后 2月为 10 98～ 15 6 0ng·ml-1;术后 3月为 934～ 12 99ng·ml-1;术后 >4月为 82 7～ 110 0ng·ml-1。结论 :环孢素的C0 与C2 都能预测不良反应和急排反应的发生 ,但C2 监测更灵敏有效。
Objective: To investigate the clinical significance of the monitoring of whole blood concentration (C2) 2 hours after the early cyclosporine administration in renal transplant recipients. Methods: C0 and C2 concentrations in 568 renal transplant recipients were measured synchronously with FPIA. The C0 and C2 concentrations in whole blood were analyzed retrospectively. The predictive value of C0 and C2 in the prediction of acute rejection and renal failure The effectiveness of the reaction. Results: The recommended range of C2 for cyclosporine is 1103 ~ 16 4 6ng · ml-1 in ≤1 months after operation and 1098 ~ 1560 ng · ml-1 in 2 months after operation, and 934 ~ 1299ng · ml-1; postoperative> April was 82 7 ~ 110 0ng · ml-1. Conclusion: Both C0 and C2 of cyclosporine can predict adverse reactions and emergency response, but C2 monitoring is more sensitive and effective.