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采用间接免疫莹光法对46例老年干部冠心病患者外周血T、B淋巴细胞亚群、免疫球蛋白、C3补体进行了测定,并与38例正常老人对比。结果显示:老年冠心病组、细胞均低于正常组(P<0.01,P<0.05);细胞比正常组高(P<0.05);细胞虽低于正常组,但无显著性差异(P>0.05);比值高于正常组也无显著性差异(P>0.05)。老年干部冠心病组中,尤以心肌梗塞患者T淋巴细胞降低为明显。结果提示:老年冠心病的发病过程中明显地存在着免疫功能的异常,免疫损伤可能为心肌梗塞的发病机制之一。
The indirect immunofluorescence method was used to determine the levels of T, B lymphocyte subsets, immunoglobulin and C3 complement in peripheral blood of 46 elderly patients with coronary heart disease and compared with 38 normal controls. The results showed that the number of cells in elderly patients with coronary heart disease was lower than that in the normal group (P <0.01, P <0.05); the cells were higher than the normal group (P <0.05) (P> 0.05). There was no significant difference between the two groups (P> 0.05). Elderly cadres coronary heart disease group, especially in patients with myocardial infarction T lymphocytes decreased significantly. The results suggest that there is obviously abnormal immune function in the pathogenesis of CHD, which may be one of the pathogenesis of myocardial infarction.