论文部分内容阅读
目的观察升降散加味治疗肺部感染合并脓毒症的临床疗效及其作用机制。方法将50例肺部感染合并脓毒症患者随机分为对照组和治疗组,每组25例;对照组给予西医常规治疗,治疗组在西医常规治疗基础上加用升降散加味,疗程7天。观察两组治疗前后中医证候积分、急性生理学及慢性健康状况(APACHEⅡ)评分、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)变化情况。结果治疗后两组中医证候积分均较治疗前降低(P<0.05),且治疗组低于对照组(P<0.05);治疗后两组患者APACHEⅡ评分、CRP、TNF-α、IL-6水平均降低(P<0.05),且治疗组低于对照组(P<0.05)。结论升降散加味治疗肺部感染合并脓毒症的主要机制是降低炎症因子以减轻炎症反应。
Objective To observe the clinical effects and its mechanism of Shengjiang Powder in treating pulmonary infection complicated with sepsis. Methods Fifty patients with pulmonary infection complicated with sepsis were randomly divided into control group and treatment group, with 25 cases in each group. The control group was treated with conventional western medicine. The treatment group was treated with Shengmai San based on routine treatment of Western medicine. The course of treatment was 7 days . The changes of TCM syndrome score, acute physiology and chronic health status (APACHEⅡ) score, C-reactive protein (CRP), tumor necrosis factor α (TNF-α) and interleukin-6 . Results After treatment, the scores of TCM syndromes in both groups were lower than those before treatment (P <0.05), and the scores of APACHEⅡscore, CRP, TNF-α, IL-6 (P <0.05), and the treatment group was lower than the control group (P <0.05). Conclusion Ascending and descending powder addictive treatment of lung infection combined with sepsis the main mechanism is to reduce the inflammatory cytokines to reduce the inflammatory response.