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目的 了解老年人急性脑血管病免疫功能的变化及临床意义。方法 检测１２８ 例患者外周血Ｔ淋巴细胞亚群和免疫球蛋白水平，并观察急性期与恢复期的动态变化。结果 脑梗死组和脑出血组外周血Ｔ细胞亚群有异常变化，ＣＤ４ 水平较正常对照组升高（Ｐ＜ ０．０５），其中脑梗死组升高更明显，６０～６９ 岁组与７０ 岁及７０ 岁以上组比较无差异，而ＣＤ８ 在脑梗死７０ 岁及以上组较６０～６９ 岁组明显下降（Ｐ＜ ０．０５）；脑出血组与脑梗死组之间外周血Ｔ淋巴细胞亚群水平的差异比较无显著意义。ＩｇＧ、ＩｇＭ 水平在两组患者中均有明显下降，与正常对照组有显著或非常显著性差异（Ｐ＜０．０５ 或Ｐ＜ ０．０１），在脑出血组下降更明显，恢复期有明显改善。结论 老年人急性脑血管病患者存在免疫功能的改变，脑梗死患者以Ｔ细胞亚群改变较明显，而脑出血患者则以免疫球蛋白改变更明显，早期预防动脉粥样硬化、改善患者的免疫功能对防治脑血管病具有一定的意义
Objective To understand the changes and clinical significance of immune function in the elderly with acute cerebrovascular disease. Methods The peripheral blood T lymphocyte subsets and immunoglobulin levels in 128 patients were detected and the dynamic changes in acute phase and convalescent phase were observed. Results There were abnormal changes of T cell subsets in peripheral blood in cerebral infarction group and cerebral hemorrhage group, and the CD4 level was higher than that in normal control group (P <0.05), especially in cerebral infarction group. There was no difference between the age group and the group over 70 years old, while CD8 decreased significantly in the group of 70 years old and older than 60-69 years old group (P <0.05). The level of T lymphocyte Subgroup level differences were not significant. IgG and IgM levels in both groups were significantly decreased, with significant difference or significant difference (P <0.05 or P <0.01), decreased more significantly in cerebral hemorrhage group, recovery period Significant improvement. Conclusion There is a change of immune function in the elderly patients with acute cerebrovascular disease. The changes of T cell subsets in patients with cerebral infarction are more obvious. The patients with intracerebral hemorrhage have more obvious changes in immunoglobulin, prevent atherosclerosis and improve immunity Function of prevention and treatment of cerebrovascular disease has a certain significance