论文部分内容阅读
T lymphocytes with dedicated suppressor function(Treg)play a crucial role in the homeostatic control of immunityin the periphery.Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations,suggesting their down-regulatory function in both human and animal models of autoimmunity,transplantation andtumor immunity.Here we will focus on the CD8 Treg population and their ability to specifically inhibit apathogenic autoimmune response.This review will detail the current advances in the knowledge of CD8 Treg in thecontext of antigen specificity,phenotype,MHC restriction,mechanism of action,and priming.Cellular &Molecular Immunology.2005;2(1):11-19.
T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Selective Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit apathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming. Cellular & Molecular Immunology. 2005; 2 (1): 11-19.