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为观察ＩＬ－２在小鼠体内抗弓形虫中的作用，应用３Ｈ－尿嘧啶（３Ｈ－Ｕ）特异性标记的弓形虫在小鼠腹腔巨噬细胞（Ｍｏｕｓｅｐｅｒｉｔｏｎｅａｌｍａｃｒｏｐｈａｇｅ，ＭＰＭ）内的增殖实验及１２５Ｉ－尿嘧啶核苷（１２５Ｉ－ＵｄＲ）标记的细胞毒实验，观察ＩＬ－２的抗弓形虫作用。结果：ＩＬ－２对ＭＰＭ的抗弓形虫作用及对ＩＦＮ－γ诱导的ＭＰＭ抗弓形虫作用无明显影响；ＩＬ－２体内应用可明显增强小鼠抗急性弓形虫感染的能力，延长小鼠生存时间；ＩＬ－２治疗组小鼠脾细胞杀伤肿瘤细胞及杀伤弓形虫自身感染靶细胞的能力，均明显高于对照组；同时也发现，对照组小鼠脾细胞几乎不能杀伤弓形虫感染的自体靶细胞。提示ＩＬ－２体内应用的抗弓形虫机制在于提高机体免疫细胞杀伤弓形虫感染细胞的能力。
To observe the role of IL-2 in anti-Toxoplasma in mice, the proliferation of Toxoplasma gondii in mouse peritoneal macrophages (MPM) using 3H-U (3H-U) - Uridine (125I-UdR) labeled cytotoxicity test to observe the anti-Toxoplasma IL-2 role. Results: IL-2 had no effect on anti-Toxoplasma gondii MPM and anti-Toxoplasma gondii MPM induced by IFN-γ. In vivo application of IL-2 could significantly enhance the ability of anti-Toxoplasma gondii infection in mice and prolong the survival of mice Time. The ability of spleen cells killing tumor cells and killing Toxoplasma gondii to self-infected target cells of IL-2-treated mice were significantly higher than that of control group. At the same time, it was found that spleen cells of control mice could hardly kill Toxoplasma gondii infection autologous Target cells. This suggests that the anti-Toxoplasma mechanism of IL-2 application in vivo is to improve the ability of immune cells to kill Toxoplasma gondii-infected cells.