目的内质网应激在多种疾病的发病机制中起到关键作用,持续或强烈的内质网应激反应可诱导细胞凋亡。作为一种内质网跨膜蛋白,活化转录因子6(ATF6)可以感受内质网应激并传递信号诱导未折叠蛋白反应。我们主要对ATF6通路以及其调控凋亡的机制进行综述,重要概述了相关激活剂和抑制剂,希望能为一些神经退行性疾病的治疗提供参考。 Endoplasmic reticulum stress plays a key role in the pathogenesis of many diseases, and persistent or intense endoplasmic reticulum stress induces apoptosis. As an endoplasmic reticulum transmembrane protein, activated transcription factor 6 (ATF6) can sense endoplasmic reticulum stress and transmit signals to induce unfolded protein responses. We mainly summarize the ATF6 pathway and the mechanism of its regulation of apoptosis, summarize related activators and inhibitors, and hope to provide reference for the treatment of some neurodegenerative diseases.