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近几年有资料报告,在休克以及应激反应时脑内吗啡样物质释放增加。并且证明吗啡样物质对心血管活动有明显的抑制作用。有人认为,休克时脑内释放的吗啡样物质可能是形成低血压的因素之一。因此设想用专一性吗啡受体阻断剂纳洛酮升高血压可能为防止休克提供一条新途径。本工作采用小剂量纳洛酮作脑室或延髓池内注射,观察它对动物的血压、心率、失血量、输液量和交感神经传出电活动的影响,初步讨论纳洛酮在抗休克治疗中的可能作用及其与交感神经活动的关系。
In recent years there are data reported in the brain during shock and stress release of morphine-like substances increased. And prove that morphine-like substances on the cardiovascular activity was significantly inhibited. Some people think that the release of morphine-like substances in the brain during shock may be one of the factors that cause hypotension. Therefore, imagine the use of specific morphine receptor blocker naloxone to increase blood pressure may provide a new way to prevent shock. This work used a small dose of naloxone for intraventricular or bulbar cistern injection, observed its effects on blood pressure, heart rate, blood loss, transfusion volume and sympathetic afferent activity in animals, preliminary discussion of naloxone in anti-shock treatment Possible role and its relationship with sympathetic activity.