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本文研究了sb-71与几种金属盐合并治疗小白鼠Ehrlich腹水癌的疗效,結果发現用硫酸銅3毫克/公斤、硫酸鋅20毫克/公斤、硫酸鎂30毫克/公斤、氯化鎂30毫克/公斤及氯化銅2.5毫克/公斤与sb-71 30毫克/公斤合并治疗小白鼠Ehrlich腹水癌时,疗效无明显变化,但硫酸銅与sb-71合并治疗組的动物一般情况較好,腹水出現較晚、腹水量亦少。用上述金属盐与sb-71 15毫克/公斤合并治疗时发現硫酸銅1.5,3毫克/公斤能显著地提高sb-71对小白鼠Ehrlich腹水癌的疗效,动物的生存时間較单用sb-71組延长,腹水量、瘤細胞浓度、瘤細胞总数亦显著減少.硫酸銅本身无治疗作用;亦不影响sb-71的毒性.在sb-71 30毫克/公斤治疗小自鼠Ehrlich腹水癌的同时投給氯化鋅3,6毫克/公斤,后者明显地拮抗Sb-7l的疗效,动物生存时間明显地短于单用sb-71組。
In this paper, the curative effect of sb-71 combined with several metal salts in the treatment of Ehrlich ascites carcinoma in mice was studied. The results showed that with 3 mg / kg of copper sulfate, 20 mg / kg of zinc sulfate, 30 mg / kg of magnesium sulfate and 30 mg / And copper chloride 2.5 mg / kg and sb-71 30 mg / kg combined treatment of mouse Ehrlich ascites cancer, the effect was no significant change, but the copper sulfate and sb-71 combined treatment group of animals generally good, ascites appear to be more Late, less amount of ascites. With the above metal salt and sb-71 15 mg / kg combined treatment found that copper sulfate 1.5,3 mg / kg can significantly improve the efficacy of sb-71 on mouse Ehrlich ascites cancer, the survival time of animals than with sb -71 group prolonged, ascites volume, tumor cell concentration, the total number of tumor cells also significantly reduced copper sulfate itself has no therapeutic effect; nor does it affect the toxicity of sb-71 in sb-71 30 mg / kg treatment of small mice Ehrlich ascites carcinoma While cast zinc chloride 3,6 mg / kg, the latter significantly antagonized the efficacy of Sb-7l, animal survival was significantly shorter than the sb-71 group alone.