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目的 :探讨增殖细胞核抗原 (PCNA)在原发性肝细胞癌 (HCC)中的表达及意义。方法 :4 3例肝细胞癌患者在B型超声引导下行肝穿刺活检获取肝癌组织标本 ,并应用免疫组织化学方法以小鼠抗人PCNA单克隆抗体检测PCNA标记指数 (PCNALI) ,观察肝癌组织PCNALI与病理组织学分级的关系。结果 :肝细胞癌穿刺组织平均PCNALI为 6 8± 2 7%。PCNALI随着Edmondson Steiner分级级别的增加而表达水平增高。高分化肝细胞组织PCNALI与无瘤肝组织PCNALI比较无统计学意义。结论 :肝细胞癌抗原PCNA是反映肝细胞癌预后的一个客观指标。
Objective: To investigate the expression of proliferating cell nuclear antigen (PCNA) in primary hepatocellular carcinoma (HCC) and its significance. Methods: Forty-three patients with hepatocellular carcinoma underwent hepatocellular biopsy under the guidance of B-mode ultrasonography to obtain the specimens of hepatocellular carcinoma. PCNA labeling index (PCNAALI) was detected by the mouse anti-human PCNA monoclonal antibody by immunohistochemistry. And histopathological grade relationship. Results: The mean PCNALI of hepatocellular carcinoma tissue was 68 ± 27%. PCNALI increased with Edmondson Steiner grade. There was no significant difference between PCNALI and PCNALI in well-differentiated hepatocytes. Conclusion: Hepatocellular carcinoma antigen PCNA is an objective indicator of the prognosis of hepatocellular carcinoma.