在炎症性肠病的研究过程中,人们开始注意到肠腔内细菌在炎症性肠病发病中的重要作用。大量临床和实验证明细菌与肠道的炎症反应有直接的联系。例如:远端回肠和结肠的细菌高密度区的解剖位点恰好是炎症性肠病病人发生炎症的常见部位。于是人们开始重视肠道共生菌群的变化,以求在细菌方面找到炎症性肠病的发病机理,并且设想用细菌及其产物来治疗炎症性肠病。 In the research of inflammatory bowel disease, people began to notice the important role of intestinal bacteria in the pathogenesis of inflammatory bowel disease. A large number of clinical and experimental evidence of bacterial and intestinal inflammation is directly linked. For example, anatomical sites in the high-density areas of the distal ileum and the colon are just the common sites of inflammation in patients with inflammatory bowel disease. So people began to pay attention to changes in intestinal commensal flora, in order to find the pathogenesis of inflammatory bowel disease in bacteria, and envisaged the use of bacteria and their products to treat inflammatory bowel disease.