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作者对336例骨髓增生异常综合征(MDS)采用单变量〔对数等级检验(log-rank tsxt)〕和多变量(logistic回归)分析,试图确定最主要的预后因素。患者分为试测组(Ⅰ组)和检验组(Ⅱ组)。Ⅰ组系1973年1月至1978年12月间收治的患者,共193例。Ⅱ组系1979年1月至1984年4月间收治的患者,共143例。每组又按骨髓中原始细胞百分比分为0-20%,0-30%和0-40%三个级别。除27例病情恶化时曾接受过化疗外,其余仅给予支持疗法。结果:1年内死亡的患者数:Ⅰ组62例(39%),Ⅱ组54例(38%);中数生存期:Ⅰ组486天,Ⅱ组557天;转白:Ⅰ组62例(32%),Ⅱ组25例(17%)。作者经统计学处理后发现,年龄、骨髓中原始细胞百分比,
The authors sought to determine the most important prognostic factors in 336 patients with myelodysplastic syndrome (MDS) using univariate log-rank tsxt and multivariate logistic regression analysis. Patients were divided into test group (group Ⅰ) and test group (group Ⅱ). Group Ⅰ was from January 1973 to December 1978 were treated patients, a total of 193 cases. Group Ⅱ was from January 1979 to April 1984 were treated patients, a total of 143 cases. Each group according to the percentage of primitive cells in the bone marrow is divided into 0-20%, 0-30% and 0-40% three levels. Except 27 patients who had received chemotherapy when their condition deteriorated, the rest were only given supportive therapy. Results: The number of deaths in one year was 62 cases in group I (39%), 54 cases in group II (38%), the median survival time was 486 days in group I and 557 days in group II, and 62 cases in group I 32%), group Ⅱ 25 cases (17%). The authors after statistical treatment found that age, the percentage of primitive cells in bone marrow,