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邻苯二甲酸酯(PAEs)是目前我国环境污染最广、检出率最高的持久性有机污染物,是一类典型的具有环境雌激素效应的化合物。作者综述了近年来国内外有关PAEs致男性生殖损害和不育的细胞及分子机制、人群流行病学研究、环境易感性和环境-基因交互作用的最新研究进展。
Phthalates (PAEs) are currently the most widely polluting and detectable POPs in China. They are typical compounds with environmental estrogenic effects. In this paper, the recent progress in cell and molecular mechanisms of PAEs-induced male reproductive impairment and infertility in China and abroad, population epidemiology, environmental susceptibility and environmental-gene interaction were reviewed.