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目的探析甲状腺良性疾病中微小癌(TMC)的检出率与临床病理特征。方法选取本院200例因各种良性疾病行甲状腺切除的甲状腺标本进行病理学检查,并对TMC病理特征进行观察。结果 200例中共检测出TMC 10例(5.0%),甲状腺微小癌在原发病分布上,甲状腺瘤及桥本病检出率明显高于其他类型疾病,差异具有统计学意义(P<0.05);10例微小癌进行病理检查,确诊乳头状癌9例(90.0%),其中具有乳头状分支,毛玻璃样核及核沟者8例(88.9%);存在假包涵体,并带有不同程度纤维间反应者5例(55.6%);3例(33.3%)可见浸润包膜、核分裂象;未见血管内癌栓患者。结论甲状腺良性疾病中微小癌的检出率较低,以乳头状癌最为常见。应事先明确甲状腺微小癌的病理类型和特点,选择适宜的治疗方法 ,以改善患者临床症状和生活质量。
Objective To investigate the detection rate and clinicopathologic features of small carcinoma (TMC) in thyroid benign disease. Methods A total of 200 thyroidectomized thyroid specimens from various benign diseases were selected for pathological examination. The pathological features of TMC were observed. Results TMC was detected in 10 out of 200 cases (5.0%). The detection rate of thyroid tumor and Hashimoto ’s disease in thyroid microcarcinoma was significantly higher than that in other types of disease (P <0.05). Nine cases (90.0%) of papillary carcinoma were diagnosed as pathological examination of micro-carcinoma. Eight cases (88.9%) had papillary branches, frosted vitreous nuclei and dacryocystitis. There were fake inclusion bodies with different degrees of inter-fiber 5 cases (55.6%) of responders; 3 cases (33.3%) showed infiltration enveloped, mitotic figures; no intravascular thrombosis patients. Conclusions The detection rate of micro-cancer in benign thyroid diseases is low, and papillary carcinoma is the most common. Thyroid cancer should be clear pathological types and characteristics of micro-cancer, select the appropriate treatment to improve patient clinical symptoms and quality of life.