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用鲎试验方法（ＬＬＴ）检测１５３例慢性肝病的肠源性内毒素发生率；比较鲎试验阳性及阴性组病人肿瘤坏死因子（ＴＮＦα）的水平；观察丽珠肠乐治疗肝病合并内毒素血症组ＬＬＴ阴转率。结果显示：①慢性肝病者ＬＬＴ阳性发生率为６５３６％，以重症肝炎最高。②ＬＬＴ阳性组ＴＮＦα水平较正常组和ＬＬＴ阴性组为高。③服丽珠肠乐治疗后，肝病合并ＬＬＴ阳性组的转阴率较对照组为高。提示慢性肝病常合并内毒素血症；ＴＮＦα在肝病所致肠源性内毒素血症发病中起重要作用；丽珠肠乐对缓解肠源性内毒素血症有效。
The incidence of intestinal endotoxin in 153 cases of chronic liver disease was detected by 鲎 test method (LLT). The levels of tumor necrosis factor (TNFα) in patients with positive and negative test were compared. The effect of Lizhuchanglele on liver disease with endotoxin Hyperlipidemia LLT negative conversion rate. The results showed that: ① The incidence of LLT in chronic liver disease was 6536%, with the highest incidence of severe hepatitis. ②LLT positive group TNF α levels were higher than normal group and LLT negative group. ③ After taking Lizhu orchestral treatment, the negative rate of LLT positive group with liver disease was higher than that of the control group. Tip chronic liver disease often associated with endotoxemia; TNF @ in liver disease caused by the pathogenesis of intestinal endotoxemia plays an important role; Lizhu intestinal music to relieve intestinal endotoxemia effective.