论文部分内容阅读
抗生素,尤其是β-内酰胺类的开发是无止境的,这些年内,层出不穷的新药剂广泛应用于临床。各种药物的抗菌活力、对β-内酰胺酶的稳定性及体内分布等的特性,在很多论文中已作过介绍,这里仅就内科领域所治疗的感染症中什么样的疾病适宜使用第三代抗生素作一介绍。研制阶段中的第三代药物的临床效果在日本化学疗法学会的新药讨论会中,已报道了研制阶段中的抗生素效果累计数字,其中所报道的第二、三代头孢菌素的有效率列于表一。唑啉头孢菌素(下称CEZ)是市售10年以上老的第一代头孢菌素。它具有抗菌活力强、血浓度高峰时间长等许多优点,
The development of antibiotics, especially β-lactams, is endless. During these years, an endless stream of new agents have been widely used clinically. The antibacterial activity of various drugs, the stability of β-lactamase and in vivo distribution characteristics have been described in many papers. Here only what kind of diseases in the treatment of infectious diseases in the medical field is suitable for use Three generations of antibiotics for an introduction. Clinical efficacy of the third-generation drugs in the research and development phase The cumulative number of antibiotics in the development phase has been reported in the Japan Society of Chemotherapy’s New Drug Symposium. The reported second- and third-generation cephalosporins are listed in Table I. Zinc oxazine cephalosporins (hereinafter referred to as CEZ) is the first-generation cephalosporins commercially available for more than 10 years. It has antibacterial activity, blood concentration and many other advantages of long peak time,