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目的 研究二甲基甲酰胺 (DMF)急性中毒诊断标准。方法 对DMF作业工人进行流行病学调查 ,分析10 4名DMF急性中毒病例 ,进行动物实验研究。结果 DMF接触工人和急性中毒病人主要表现为头晕、头痛、恶心、腹痛、上腹部压痛、肝区叩痛等。动物实验染毒组血清丙氨酸转氨酶 (ALT)升高 ,与对照组比差异有非常显著性 (P <0 0 1) ;尿蛋白升高、肾小球充血、肾小管浊肿等 ,表明肝、肾有一定的损伤。结论 DMF是以消化系统尤其肝脏为主要靶器官的毒物。初步提出了DMF急性中毒的诊断标准。
Objective To study the diagnostic criteria of dimethylformamide (DMF) acute poisoning. Methods An epidemiological investigation of DMF workers was conducted and 104 acute cases of DMF poisoning were analyzed for animal experiments. Results DMF exposure workers and acute poisoning patients mainly manifested as dizziness, headache, nausea, abdominal pain, upper abdominal tenderness, percussion pain in the liver area. In animal experiments, the level of serum alanine aminotransferase (ALT) in the exposed group was significantly higher than that in the control group (P <0.01); the elevated urinary protein, glomerular hyperemia and tubular turbidity were found Liver, kidney have some damage. Conclusion DMF is a toxicant that takes digestive system, especially liver as the main target organ. Preliminary proposed the diagnostic criteria for acute poisoning of DMF.