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目的分析2015年9月~2016年12月北京怀柔医院312例消化不良患者经13C呼气试验检测幽门螺杆菌(H.pylori,Hp)为阳性者再行免疫印迹法Hp分型结果。方法采用免疫印迹法进行血清学分析,检测结果采用χ2检验。结果 312例中共检测出阳性结果302例,阳性率96.7%,其中Ⅰ型235例,占总阳性77.8%(235/302);Ⅱ型67例,占总阳性22.2%(67/302)。男156例,女146例,按年龄分为青年、中年、老年三组,年龄组间阳性率和分型进行χ2检验,老年组阳性率高,P<0.05。结论免疫印迹法适合门诊消化不良患者的幽门螺杆菌感染检测,可以使抗幽门螺杆菌治疗精准化。
Objective To analyze the Hp typing results of 312 cases of dyspepsia patients who were positive in H. pylori (Hp) by 13C breath test from September 2015 to December 2016 in Beijing Huairou Hospital. Methods Serological analysis was performed by Western blotting. The test results were analyzed by χ2 test. Results A total of 302 positive cases were detected in 312 cases, with a positive rate of 96.7%. Among them, 235 cases were type Ⅰ, accounting for 77.8% (235/302) of type Ⅰ and 67 cases of type Ⅱ, accounting for 22.2% (67/302) of the total. There were 156 males and 146 females, which were divided into three groups according to their ages: young, middle-aged and old. The positive rates and genotypes among the age groups were analyzed byχ2 test. The positive rate of the elderly group was higher (P <0.05). Conclusion Western blotting is suitable for the detection of Helicobacter pylori infection in outpatients with dyspepsia, which can make anti-Helicobacter pylori treatment more accurate.