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对91例原发性高脂血症患者随机分为三组．分别应用普伐他汀（P）、非诺贝特（F）、鱼油（FO）12周，比较三种血脂调节剂服药疗效及对血浆超氧化物歧化酶（SOD）、丙二醛（MDA）及其平衡的影响。结果治疗后三组甘油三酯（TG）、低密度脂蛋白（LDL－C）、载脂蛋白B100（ApoB100）均明显降低（P＜0．05）；高密度脂蛋白（HDL－C）均升高，但仅F组有显著意义（P＜0.05）：降胆固醇（TC），P组、F组显著（P＜0.05）：HDL-C与TG三组均呈负相关（P＜0．05）。血浆MDA水平三组均显著降低（P＜0.01）．SOD无差异，MDA／SOD比值三组均下降。P组F组显著（P＜0．05）。血清TC、TG、LDL-C下降与血浆MDA／SOD比值的相关性，TC与MDA／SOD比值：P组、F组显著（P＜0.01）；TG与MDA／SOD：三组均显著正相关（P＜0.001）；LDL-C与MDA／SOD：F组、FO组呈显著正相关（P＜0．001）。
91 cases of primary hyperlipidemia were randomly divided into three groups. The curative effect of three kinds of blood lipid regulators and their effects on the levels of plasma superoxide dismutase (SOD), malondialdehyde (MDA) and malondialdehyde (MDA) were compared by using pravastatin (P), fenofibrate And its balance of influence. Results After treatment, triglyceride (TG), low density lipoprotein (LDL-C) and apolipoprotein B100 (ApoB100) in three groups were significantly decreased (all P <0.05); high density lipoprotein (P <0.05). There was a significant correlation between HDL-C and TG (P <0.05). There was a significant correlation between HDL-C and TG (P <0.05) 05). Plasma MDA levels were significantly reduced in all three groups (P <0.01). SOD was no difference, MDA / SOD ratio decreased in all three groups. P group F group was significant (P <0.05). The correlation between serum TC, TG, LDL-C and plasma MDA / SOD ratio, the ratio of TC to MDA / SOD: P group and F group were significant (P <0.01); TG and MDA / SOD: (P <0.001). There was a significant positive correlation between LDL-C and MDA / SOD: F group and FO group (P <0.001).