茶碱治疗新生儿窒息有效最早报道于1973年。在许多医疗机构中,茶碱都被认为是治疗窒息的一种可选性药物,其可口服,也可静脉注射。氨茶碱盐栓剂通过直肠溶解也很有效。然而,这些剂型并不理想,静脉注射有损害性;口服吸收导致胃酸缺乏,延长胃排空或无法预报的肠蠕动;用栓剂不易达到给 Theophylline treatment of neonatal asphyxia effective first reported in 1973. In many medical institutions, theophylline is considered as an optional drug for the treatment of asphyxia, which can be taken orally or intravenously. Aminophylline salt suppositories are also effective when dissolved in the rectum. However, these formulations are not ideal, intravenous damage; oral absorption leads to acid deficiency, prolonged gastric emptying or unpredictable bowel movements; with suppositories difficult to achieve