运用培养新生小鼠颅盖评价骨吸收抑制活性,对显示强活性的川羌活(Notopterygium forbesii)的活性成分进行了研究。 以对PTHrp(1-34)培养的新生小鼠颅盖中钙及无机磷游离的抑制作用为指标研究骨吸收抑制活性。并以PTHrp(1-34)诱发高钙血症大鼠探讨体内试验的效果。川羌活的活性成分是将其甲醇提取物以溶剂分离,再经 The neonatal mouse calvaria was used to evaluate the bone resorption inhibitory activity, and the active ingredient of Notopterygium forbesii showing strong activity was studied. The bone resorption inhibitory activity was studied using the inhibition of calcium and inorganic phosphorus in the calvaria of newborn mice cultured with PTHrp(1-34) as an index. Rats with hypercalcemia induced by PTHrp(1-34) were studied for their effects in vivo. The active ingredient of Rhizoma Chuanxiong is to separate the methanol extract from the solvent and then