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病毒性肝炎是由多种肝炎病毒引起的一组全身性传染病。其中乙型、丙型多呈慢性感染,少数病例可发展为肝硬化或肝细胞癌。辅助性T细胞( Th17)细胞是近年来发现的不同于Th1、Th2及调节性T细胞( Treg)细胞的CD4+T细胞亚群,IL-17是Th17细胞的重要效应因子,具有强大的促炎作用,维甲酸相关核孤儿受体γt则是其重要的转录因子。有研究发现Th17细胞能够抑制T淋巴细胞的细胞不良反应,增加肝炎病毒的持续感染,导致肝炎的慢性化。“,”Viral hepatitis is a systemic infectious disease caused by variety hepatitis virus. Hepatitis B and C are often chronic infection,and a few of hepatitis B and C can develop into liver cirrhosis or hepatocel-lular carcinoma. Helper T cell (Th17) discovered in recent years is a subset of CD4 +T cells,different from Th1 cells,Th2 cells and regulatery T cell (Treg),interleukin-17(IL-17) is a significant effector molecule of Th17 cell,with strong pro-inflammatory effect,and retinoic acid-related orphan receptor γ t( RORγt) is an important transcriptive factor of Th17 cell. Studies have found that Th17 cell can suppress adverse reactions of T lymphocyte,increase persistent infection of hepatitis virus,and lead to chronicity of hepatitis.