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采用酰氯法和活化酯法合成了14个未见文献报道的α-(7-取代香豆素-3-甲酰胺)苯乙酰胺头孢菌素。通过葡聚糖凝胶(Scphadcx LH-20)柱层析、离心薄层层析纯化精制。由红外光谱、元素分析和核磁共振谱确证其化学结构。初步抗菌试验表明,对某些革兰氏阳性菌有不同程度的抑制作用,但对革兰氏阴性菌无效。
Fourteen novel α - (7 - substituted coumarin - 3 - carboxamides) phenylacetamide cephalosporins were synthesized by acid chloride method and activated ester method. Purification by Sephadex LH-20 column chromatography and purification by thin-layer chromatography. Its chemical structure was confirmed by IR, elemental analysis and nuclear magnetic resonance spectroscopy. Preliminary antibacterial tests showed that some of Gram-positive bacteria have different degrees of inhibition, but no effect on Gram-negative bacteria.