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目的探讨人乳头瘤病毒１６、１８两型是否参与膀胱癌的形成。方法应用聚合酶链反应技术检测青岛地区４８例膀胱癌、１６例膀胱乳头状瘤及１７例正常膀胱粘膜组织ＨＰＶ—１６、１８两亚型特异性ＤＮＡ片段。结果发现ＨＰＶ—１８与膀胱癌发生无关。ＨＰＶ—１６与膀胱癌及膀胱乳头瘤发生相关。ＨＰＶ—１６ＤＮＡ阳性率与膀胱癌的分级、分期、初发或复发无关；膀胱癌和膀胱乳头状瘤组织中ＨＰＶ—１６ＤＮＡ阳性率无显著差异。结论ＨＰＶ—１６型可能参与膀胱癌的早期形成。
Objective To investigate whether human papillomavirus types 16 and 18 are involved in the formation of bladder cancer. Methods 48 cases of bladder cancer, 16 cases of papilloma of the bladder and 17 cases of normal bladder mucosa tissue-specific HPV-16,18 subtype were detected by polymerase chain reaction (PCR). The results found that HPV-18 and bladder cancer has nothing to do. HPV-16 is associated with bladder cancer and bladder papilloma. The positive rate of HPV-16 DNA was not related to the grade, stage, initial or recurrence of bladder cancer. There was no significant difference in the positive rate of HPV-16 DNA between bladder cancer and papillary papillary tumor. Conclusion HPV-16 may be involved in the early formation of bladder cancer.