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补体(Complement)是存在于正常人和动物血清中的具有酶活性的一组球蛋白。占血清球蛋白总量的10％。其含量不因免疫接种而增加。补体的主要作用有杀菌、溶菌、灭活病毒以及溶解细胞等。它不仅参与了机体自身稳定的保护性反应,还可引起免疫病理的损伤性反应。近年来,由于对补体及其病理生理研究的深入,补体测定的临床意义和应用,也得到广泛的重视。本文拟结合文献,就补体的病理生理变化及其临床应用,简要介绍如下。
Complement is a group of globulin with enzymatic activity found in normal human and animal sera. Accounting for 10% of the total serum globulin. Its content is not increased by immunization. The main role of complement has bactericidal, bacteriolytic, inactivated virus and dissolved cells. It not only involved in the body’s own stable protective reaction, but also can cause immunopathological damage response. In recent years, due to the in-depth study of complement and its pathophysiology, the clinical significance and application of complement determination have received extensive attention. This article to be combined with the literature on the pathophysiology of complement changes and its clinical application, briefly described below.