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苯丁亮氨酸(Bestatin,曾译抑氨肽酶B)是一种由放线菌产生的二肽,对存在于淋巴细胞表面的氨肽酶B及亮氨酸氨肽酶有竞争性抑制作用,为一有效的免疫调节剂。该品经过一系列的毒理、药效及一般药理研究,已进入第二期临床研究阶段。在肿瘤的治疗方面取得了肯定的效果。与其他作用于免疫系统的药物相比,该品的特点是安全无毒、用药剂量小、口服吸收良好、化学结构及作用部位明确,并有可靠的控制产品质量的理化及生物方法。该品通过以细胞为中介的免疫系统,促进释出各种淋巴因子,修复和保护机体的免疫功能。在肿瘤的治疗过程中其主要的作用为: 1.保护和修复肿瘤患者的免疫功能,延长生存期。 2.与常用的抗肿瘤化疗药物有显著协同作用,可强化药物的治疗效果、降低化疗药物的治疗剂量、减少毒副作用。配合放疗也有类似的作用。 3.防止肿瘤的转移及抑制化学致癌剂的诱发肿瘤作用 4.促进肿瘤细胞的重分化趋势。这种免疫调节剂在肿瘤及免疫缺损患者的抗感染治疗中可能有较大的潜在价值。本刊将有关苯丁亮氨酸药效学方面的部分研究资料组织摘译后集中刊出,以期能引起读者的注意和兴趣。
Bestatin (alanine aminopeptidase B) is a dipeptide produced by actinomycetes that competitively inhibits aminopeptidase B and leucine aminopeptidase present on the surface of lymphocytes Role as a potent immunomodulator. The product after a series of toxicology, pharmacodynamics and general pharmacological studies, has entered the second phase of clinical research. In the treatment of cancer has made a positive effect. Compared with other drugs acting on the immune system, this product is characterized by safe and non-toxic, small dosage, good oral absorption, clear chemical structure and site of action, and reliable physical, chemical and biological control of product quality. The product through the cell-mediated immune system, promote the release of various lymphokines, repair and protection of the body’s immune function. In the course of tumor treatment its main role is: 1. To protect and repair the immune function of cancer patients and prolong survival. 2. And commonly used anti-tumor chemotherapy drugs have a significant synergy, can enhance the therapeutic effect of drugs, reduce the dose of chemotherapy drugs, reduce side effects. With radiotherapy have a similar effect. 3. To prevent the transfer of cancer and inhibit the carcinogenic effect of chemical carcinogens 4. To promote the trend of re-differentiation of tumor cells. This immunomodulator may have greater potential value in the anti-infective treatment of patients with tumors and immunodeficiencies. This publication will be part of the phentermine leucine pharmacological aspects of the organization of extracts after the publication of a concentrated publication, with a view to arouse the reader’s attention and interest.