肿瘤源性骨软化症(tumor～induced osteomalacia,TIO)是一种罕见的综合征,主要特征包括低磷血症,尿磷排出大量增加,血1,25(OH)_2D_3浓度降低,以及骨软化症。放射学及组织学检查可显示患者有骨软化症或佝偻病的表现。切除肿瘤后该病可得到治愈。磷自肾脏大量排出、丢失,肠道磷吸收降低,以及细胞内磷再分布等均可导致低磷血症。一些研究表明,肿瘤组织含有一种小于 Tumor-induced osteomalacia (TIO) is a rare syndrome characterized by hypophosphatemia, increased urinary phosphorus excretion, reduced blood 1,25(OH)2D3 levels, and osteomalacia. disease. Radiological and histological examinations can show patients with osteomalacia or rickets. The disease can be cured after removal of the tumor. Phosphorus is excreted and lost from the kidneys, the absorption of intestinal phosphorus is reduced, and the redistribution of phosphorus in the cells can lead to hypophosphatemia. Some studies have shown that tumor tissue contains a smaller