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目的:综合评价人乳头状瘤病毒(human papillomavirus,HPV)感染与食管癌发生的相关性.方法:检索1987-01/2008-11国内外公开发表的有关我国人群食管癌和正常食管组织中HPV感染的文献报道.研究纳入标准是以聚合酶链反应和/或原位杂交法检测HPVDNA的食管癌病例-对照研究,对所得资料进行Meta分析.结果:共有15组病例-对照研究符合入选标准,累积食管癌患者1174例和正常对照人群988例.Meta分析显示,食管癌组织中HPV感染的合并优势比是正常食管组织的4.29倍(95%CI:2.38-7.70).食管癌组织和正常食管组织中HPV的平均感染率在高发区均显著高于低发区(59.26%vs34.66%,χ2=66.05,P<0.001;42.50%vs15.82%,χ2=66.02,P<0.001).结论:人乳头状瘤病毒感染可增加国人食管癌发生的危险性,尤其是在食管癌高发区.
Objective: To evaluate the correlation between human papillomavirus (HPV) infection and the occurrence of esophageal cancer.Methods: The clinical data of HPV in human esophageal cancer and normal esophageal tissues from 1987 to 2008 in China were searched. Infection reported in the literature.Research inclusion criteria were polymerase chain reaction and / or in situ hybridization detection of HPVDNA case-control study of esophageal cancer, the data were analyzed by meta-analysis.Results: A total of 15 cases of control group met the inclusion criteria , 1174 cumulative esophageal cancer patients and 988 normal control subjects.Meta analysis showed that the combined advantage of HPV infection in esophageal cancer tissues was 4.29 times (95% CI: 2.38-7.70) compared with that of normal esophageal tissues.The esophageal cancer tissues and normal The average infection rate of HPV in esophageal tissue in high incidence area was significantly higher than in low incidence area (59.26% vs34.66%, χ2 = 66.05, P <0.001; 42.50% vs15.82%, χ2 = 66.02, P <0.001). Conclusion: Human papillomavirus infection can increase the risk of esophageal cancer in Chinese people, especially in the high incidence area of esophageal cancer.