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异常的血清免疫球蛋白常伴发于甲亢与甲低,促甲状腺素(TSH)结合抑制性免疫球蛋白(TBII)和甲状腺刺激抗体(TS-ab)可在90%未经治疗的Graves患者中检出。尽管一般都认为这些抗体在甲亢的发病中起重要作用,但事实上并非完全如此。如甲状腺刺激阻滞抗体(TSB-ab)曾在许多伴有慢性甲状腺炎的甲低病人中发现。作者认为,实际情况比较复杂,某些病人有Graves病的临床表现和慢性甲状腺炎的免疫学及组织学征候。曾报告这类病人当有甲亢时便伴发桥本氏甲状腺炎的组织学变化。
Abnormal serum immunoglobulins are commonly found in hyperthyroidism and hypothyroidism. Thyrotropin (TSH) combined with inhibitory immunoglobulin (TBII) and thyroid stimulating antibody (TS-ab) are found in 90% of untreated Graves Check out. Although it is generally accepted that these antibodies play an important role in the pathogenesis of hyperthyroidism, this is not exactly the case. Thyroid stimulating block antibodies (TSB-ab) have been found in many hypothyroid patients with chronic thyroiditis. The authors believe that the actual situation is more complicated, some patients have clinical manifestations of Graves disease and immunological and histological signs of chronic thyroiditis. Hyperthyroidism was reported when such patients with Hashimoto’s thyroiditis histological changes.