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目的：研究诱导性一氧化氮合酶抑制药氨基胍（ＡＧ）对感染性休克犬生化的影响。方法：杂种犬在２ ｈ 输注内毒素（ＬＰＳ， １ ｍ ｇ／ｋｇ），在血压下降至基础值６０％ ２ ｈ 后随机分为ＬＰＳ（组Ⅰ）组，ＬＰＳ＋ Ｌ－ＮＡＭＥ（组Ⅱ）组和ＬＰＳ＋ ＡＧ（组Ⅲ）组，分别给予生理盐水，Ｌ－ＮＡＭＥ（３０ ｍ ｇ／ｋｇ）和ＡＧ（２０ ｍ ｇ／ｋｇ）。分别监测血中ＮＯ、血乳酸、丙氨酸转氨酶（ＬＡＴ）、门冬氨酸转氨酶、尿素氮和血糖。观察到给予治疗后４ ｈ。结果：平均动脉压下降２ ｈ 后，３ 组的血ＮＯ、乳酸、尿素氮、门冬氨酸转氨酶和丙氨酸转氨酶明显增加，血糖明显减少。给予治疗后，组Ⅱ乳酸、尿素氮、门冬氨酸转氨酶和丙氨酸转氨酶均明显高于其它两组（ Ｐ＜ ０．０５）；血糖在各时间段均明显减少。组Ⅲ乳酸、尿素氮、丙氨酸转氨酶明显低于其它两组（Ｐ＜ ０．０５）；血糖明显增高（ Ｐ＜ ０．０５）。结论：选择性地抑制ｉＮＯＳ减少ＮＯ的产生对感染休克的治疗效果好于非选择性地抑制ＮＯＳ
Objective: To study the effect of inducible nitric oxide synthase inhibitor aminoguanidine (AG) on the biochemistry of septic shock dogs. Methods: The dogs were randomly divided into three groups: LPS (group Ⅰ), LPS + L-NAME (group Ⅱ), LPS Group and LPS + AG group (Group Ⅲ) were given normal saline, L-NAME (30 m g / kg) and AG (20 m g / kg) respectively. Blood NO, blood lactate, alanine aminotransferase (LAT), aspartate aminotransferase, urea nitrogen and blood glucose were monitored. 4 h after treatment was observed. Results: The mean arterial pressure decreased 2 h after the three groups of blood NO, lactate, urea nitrogen, aspartate aminotransferase and alanine aminotransferase increased significantly, blood glucose decreased significantly. After treatment, the levels of lactic acid, urea nitrogen, aspartate aminotransferase and alanine aminotransferase in group Ⅱ were significantly higher than those in the other two groups (P <0.05); blood glucose was significantly decreased in each time period. Group Ⅲ lactic acid, urea nitrogen, alanine aminotransferase was significantly lower than the other two groups (P <0.05); blood glucose was significantly higher (P <0.05). CONCLUSION: Selective inhibition of iNOS to reduce NO production is more effective in treating septic shock than non-selective inhibition of NOS