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自身免疫性甲状腺病 (ＡＩＴＤ)是一组器官特异性自身免疫疾病。主要包括Ｇｒａｖｅｓ病 (ＧＤ)、桥本甲状腺炎 (ＨＴ)和原发性粘液性水肿。促甲状腺激素受体 (ＴＳＨＲ)是ＡＩＴＤ发病中重要的自身抗原 ,对其遗传变异的研究具重要意义。人类ＴＳＨＲ基因位于染色体 14ｑ31处 ,
Autoimmune thyroid disease (AITD) is a group of organ-specific autoimmune diseases. Mainly include Graves disease (GD), Hashimoto’s thyroiditis (HT) and primary myxedema. Thyroid-stimulating hormone receptor (TSHR) is an important autoantigen in the pathogenesis of AITD, and it is of great significance to study its genetic variation. The human TSHR gene is located at chromosome 14q31,