建立了成骨细胞和破骨细胞共同培养体系,探讨了白细胞介素-1(IL1)促进骨吸收的作用机理。研究发现,破骨细胞+IL1组的骨吸收陷窝数目和面积,与单纯破骨细胞组比较,差异无显著性意义。破骨细胞+成骨细胞+IL1组,骨吸收陷窝数目和面积均显著增加,与破骨细胞+IL1组及单纯破骨细胞对照组比较,差异均有显著性意义。提示IL1对破骨细胞缺乏直接作用,而是在成骨细胞介导下,发挥调节破骨细胞的骨吸收作用。 Established co-culture system of osteoblasts and osteoclasts to explore the mechanism of interleukin-1 (IL1) to promote bone resorption. The study found that osteoclasts + IL1 group, the number and area of ​​bone resorption lacuna, compared with the simple osteoclast group, the difference was not statistically significant. Osteoclasts + osteoblasts + IL1 group, the number and area of ​​bone resorption lacquers increased significantly compared with the osteoclasts + IL1 group and the simple osteoclast control group, the differences were significant. Tip IL1 lack of a direct role of osteoclasts, but under the guidance of osteoblasts, play a role in regulating bone resorption of osteoclasts.