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目的探讨肺上皮样血管内皮瘤(PEH)的临床病理特征、诊断与鉴别诊断。方法应用HE和免疫组化染色对3例孤立性PEH的临床病理特征、免疫表型进行分析,并结合文献讨论。结果 PEH表现为肺内孤立性结节,镜下肿瘤呈明显分带,肿瘤周边细胞丰富,中央硬化,肿瘤细胞为圆形或多角形,具有上皮样细胞形态,呈巢状、条索状、腺样结构,肿瘤间质玻璃样变性或黏液样变性。瘤细胞胞质内见空腔形成。肿瘤细胞血管内皮标记(+)。结论 PEH是低度恶性血管源性肿瘤,其病理形态具有一定特征,主要依靠组织病理学和免疫组化确诊。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of pulmonary epithelioid hemangioendothelioma (PEH). Methods The clinical and pathological features, immunophenotypes of 3 cases of isolated PEH were analyzed by HE and immunohistochemistry, and the literature was discussed. Results PEH showed solitary nodules in the lung. The microscopic tumor was obviously zonated, with abundant peritumoral cells, central sclerosis and round or polygonal tumor cells with epithelial cell morphology. Nephridial, cordlike, Adenoid structures, interstitial glassy degeneration or mucoid degeneration. See the cytoplasm of the tumor cavity formation. Tumor cell vascular endothelial marker (+). Conclusion PEH is a low-grade malignant tumor of vasculature. The pathological features of PEH are characterized by histopathology and immunohistochemistry.