目的：进一步研究ＧＡＰ４３（生长相关蛋白４３）在周围神经损伤和再生中的表达部位及其作用。方法：采用免疫电镜技术对６只大鼠坐骨神经损伤和再生中的ＧＡＰ４３表达情况作初步观察。结果：电镜观察发现大鼠腰骶髓神经元、背根神经节神经元、胶质细胞等胞浆和胞核中均有密集的ＧＡＰ４３免疫反应颗粒沉积。结论：据结果和笔者先前的ＧＡＰ４３免疫组化研究，发现周围神经损伤和再生中，可引起ＧＡＰ４３较广泛的表达；其表达以神经元胞体为主，逐渐向损伤处运送，在神经再生中可能起着重要作用。 Objective: To further study the expression of GAP43 (growth-associated protein 43) in peripheral nerve injury and regeneration and its role. Methods: Immuno-electron microscopy was used to observe the expression of GAP43 during the sciatic nerve injury and regeneration in 6 rats. Results: Electron microscopy showed that GAP43-immunoreactive particles were densely distributed in the cytoplasm and nucleus of rat lumbosacral spinal cord neurons, dorsal root ganglion neurons and glial cells. Conclusion: According to the results and the author’s previous GAP  43 immunohistochemical study found that peripheral nerve injury and regeneration, can cause a more extensive expression of GAP  43; expression of neuronal somatic cells gradually transported to the injury at Nerve regeneration may play an important role.