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异丁基哌嗪力复霉素(利福定,R76-1)为我国合成的力复霉素类新抗生素。本文报告~3H-异丁基哌嗪力复霉素用液闪法及整体放射自显影法,进行小鼠体内的药物代谢动力学研究。试验结果表明~3H-R76-1口服吸收慢而且不完全。口服后6小时血浆药物浓度达到
Isobutylpiperazine erythromycins (Rifidin, R76-1) for the synthesis of our new line of antibiotics ADM. This article reports ~ 3H-isobutylpiperazine microruin by liquid scintillation method and the whole autoradiography, pharmacokinetics of mice in vivo. Test results show ~ 3H-R76-1 oral absorption slow and incomplete. 6 hours after oral administration of plasma drug concentration reached