“对亚甲基苯醌(para-Quinone Methides,p-QMs)”是有机化学中一类结构独特的重要醌类衍生物,其结构单元广泛存在于自然界多类天然产物中,如真菌代谢物、萜烯、植物色素等.此外,对亚甲基苯醌还是许多生物合成、药物代谢过程中的关键活性中间体.在有机化学中,关于“对亚甲基苯醌”的文献报道最早可以追溯至20世纪初,但在过去的一个多世纪中,其反应研究大多仅局限于一些非手性的转化报道,鲜有基于不对称催化的加成反应研究.最近,兰州大学功能有机分子化学国家重点实验室樊春安研究小组基于不对称相转移催化过程,成功实现了一类新颖 “Para-Quinone Methides (p-QMs)” is a class of quinone derivatives with unique structure and unique structure. Its structural units are widely found in many natural products in nature, such as fungi Metabolites, terpenes, plant pigments, etc. In addition, p-benzoquinone is also a key active intermediate in many biosynthesis and drug metabolism processes.In organic chemistry, p-benzoquinone Literature reports can be traced back to the early 20th century, but in the past more than a century, most of its reaction research is limited to some non-chiral transformation reports, few based on asymmetric catalytic addition reaction.Recently, Lanzhou University FAN Chun’an, State Key Laboratory of Functional Organic Chemistry, based on the asymmetric phase transfer catalysis, succeeded in realizing a novel