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应用ＳＡＢＣ法检测了５６例卵巢上皮性癌（ＯＥＣ）的ｎｍ２３Ｈ１的蛋白表达，并对其表达与临床病理因素的关系进行了分析。结果表明ＯＥＣ组织ｎｍ２３Ｈ１的表达率为５５．３６％，表达水平与淋巴结转移呈负相关（Ｐ＜０．０１），其阳性表达是淋巴结转移的保护因素，ＯＲ＝０．２７，阳性表达组与阴性表达组的５ａ生存率分别为５２．９８％和３２．８３％，差异有显著性（Ｐ＜０．０５），Ｃｏｘ回归模型多因素分析未提示ｎｍ２３Ｈ１表达是ＯＥＣ的独立预后因素。可见ｎｍ２３Ｈ１基因对卵巢癌淋巴结转移具有抑制作用，但作为判断预后指标尚需进一步验证。
The protein expression of nm23 H1 in 56 cases of ovarian epithelial carcinoma (OEC) was detected by SABC method and its relationship with clinicopathological factors was analyzed. The results showed that the expression rate of nm23 H1 in OEC was 55.36%, the expression level was negatively correlated with lymph node metastasis (P <0.01), and the positive expression was the protective factor of lymph node metastasis, OR = 0.27 The survival rates of group 5a and group A5 were 52.98% and 32.83%, respectively (P <0.05). Multivariate analysis of Cox regression model did not suggest that nm23-H1 expression was an independent prognostic factor for OEC factor. Visible nm23 Hl gene on the lymph node metastasis of ovarian cancer has an inhibitory effect, but as a prognostic indicator still needs further verification.