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本文对80例正常人与120例原发性高血压患者,常规尿检验蛋白阴性或微量,用精确的定量法测定尿微量Alb及IgG、A、M浓度.发现高血压患者尿内上述蛋白排泄率均明显高于正常人,分别为P<0.001、P<0.01、P<0.01、P<0.01,其中Alb、IgG与测定时血压相关(SBP与尿Alb:P<0.01,DBP与尿Alb:P<0.05,DBP与尿IgG:P<0.05).用IgG清除率/alb清除率配对比较发现原发性高血压患者的比值明显高于正常人(P<0.001)。进一步将高血压患者按WHO标准分成三期,发现此比值进行性减低(分别为1.47±2.06,1.11±1.04,0.895±0.81;与正常人比分别为P<0.2,P<0.001,P<0.02)。上述结果可见原发性高血压患者有明显升高的尿IgG、Alb排泄率,并与血压相关,随着高血压病进一步发展,从Ⅰ期～Ⅲ期,尿白蛋白排泄率进行性增加,其增加程度比IgG更明显,提示尿Alb是高血压病引起血管损伤及肾血管早期病变的敏感指标。
In this paper, 80 cases of normal and 120 cases of patients with essential hypertension, routine urine test protein negative or trace determination of microalbuminuria and IgG, A, M concentrations using accurate quantitative method found in urine of patients with hypertension urinary excretion of these proteins (P <0.001, P <0.01, P <0.01, P <0.01, respectively). Alb and IgG were correlated with blood pressure (SBP and urinary Alb: P <0.01, DBP and urinary Alb: P <0.05, DBP and urinary IgG: P <0.05) .It was found that the ratio of IgG clearance / alb clearance was significantly higher in patients with essential hypertension than in normal people (P <0.001). Hypertensive patients were further divided into three stages according to the WHO standard and the ratio was found to decrease progressively (1.47 ± 2.06, 1.11 ± 1.04, 0.895 ± 0.81 respectively; P <0.2, P <0.001, P <0.02, respectively ). The above results show that patients with essential hypertension significantly increased urinary IgG, Alb excretion rate, and with blood pressure, with the further development of hypertension, from Ⅰ to Ⅲ, urinary albumin excretion rate increased sexually, The increase is more pronounced than IgG, suggesting that urinary Alb is a sensitive marker of vascular damage and early renal vascular disease in hypertensive patients.