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目的:探讨抗焦虑抑郁治疗能否减少冠心病伴焦虑抑郁患者常规抗血小板治疗后出血事件发生率。方法:选择冠心病伴焦虑抑郁患者134例,随机分为A组(常规抗血小板,63例)和B组(常规抗血小板+抗焦虑抑郁,71例),分别观察两组3个月和12个月的出血情况。结果:3个月A组出血发生率28.57%(18/63),SAS(SDS)量表平均得分(68.23±11.45);B组出血发生率9.86%(7/71),SAS(SDS)量表平均得分(61.17±10.64);均差异有统计学意义(均P<0.05)。12个月A组出血发生率33.33%(21/63)例,SAS(SDS)量表平均得分(70.01±8.28);B组出血发生率12.68%(9/71),SAS(SDS)量表平均得分(56.98±9.76);均差异有统计学意义(均P<0.05)。结论:抗焦虑抑郁治疗能显著减少冠心病伴焦虑抑郁患者常规抗血小板的出血事件发生率。
Objective: To investigate whether anti-anxiety and depression treatment can reduce the incidence of bleeding after conventional anti-platelet therapy in patients with coronary heart disease and anxiety and depression. Methods: A total of 134 CHD patients with anxiety and depression were randomly divided into three groups: A (conventional antiplatelet, 63 cases) and B (conventional antiplatelet + anti anxiety and depression, 71 cases) Month of bleeding. Results: The incidence of hemorrhage in group A was 28.57% (18/63) at 3 months, the average score of SAS (SDS) was 68.23 ± 11.45, the rate of hemorrhage in group B was 9.86% (7/71), the amount of SAS Table average score (61.17 ± 10.64); The difference was statistically significant (P <0.05). The incidence of hemorrhage in group A was 33.33% (21/63) in 12 months, the average score of SAS (SDS) was 70.01 ± 8.28; the rate of hemorrhage in group B was 12.68% (9/71) The average score (56.98 ± 9.76); There was significant difference between the two groups (all P <0.05). Conclusion: Anxiolytic depression treatment can significantly reduce the incidence of conventional antiplatelet bleeding in patients with coronary heart disease and anxiety and depression.