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目的:对影响多发性骨髓瘤预后的检查结果、临床特征及治疗方案等因素进行分析研究。方法:收集2009年7月—2011年7月期间的50例多发性骨髓瘤患者预后的有关资料,30例患者采用化疗方法治疗,20例患者基于此同时合并放疗治疗方法。对患者治疗过程中有关指标的变化进行比较,治疗后进行1—5年时间的随访,分析影响患者预后的因素。结果:有14例患者病灶消失(占28%),24例患者部分缓解良好(占48%),7例患者部分缓解(占14%),总有效率达90%。随访5年后有31例患者死亡,年龄、复杂核型、重度贫血、截瘫等都属于对患者预后具有影响的因素,患者之间存在的差异不具有统计意义(P<0.05)。结论:影响多发性骨髓瘤患者的因素十分复杂,老年患者、同时存在低蛋白血症、重度贫血、截瘫等患者不具有良好预后效果,患者应用沙利度胺维持治疗可在一定程度上延长生存期,分析影响患者预后的危险因素对于预测患者临床疗效具有重要重要作用。
Objective: To analyze the prognosis of multiple myeloma prognosis, clinical characteristics and treatment options and other factors. Methods: The data of 50 patients with multiple myeloma from July 2009 to July 2011 were collected. Thirty patients were treated with chemotherapy and 20 patients were treated with concurrent radiotherapy. During the treatment of patients with changes in the indicators were compared after treatment for 1 to 5 years follow-up, analysis of prognostic factors in patients. Results: Fourteen patients had disappeared lesions (28%), 24 patients achieved partial remission (48%), 7 patients partially relieved (14%) and the total effective rate reached 90%. After 5 years of follow-up, 31 patients died. Age, complex karyotype, severe anemia and paraplegia all belong to the prognostic factors. The difference between the two groups was not statistically significant (P <0.05). Conclusion: The factors affecting multiple myeloma patients are very complicated. Elderly patients with congenital hypoproteinemia, severe anemia, paraplegia and other patients do not have a good prognosis, and patients with thalidomide maintenance therapy can be extended to some extent The analysis of the risk factors influencing the prognosis of patients plays an important role in predicting the clinical efficacy of patients.