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对138例CHB患者进行HBV基因分型,检测非特异性CTL,HBV特异性CTL,肝功能,HBVDNA,HBVM(HBsAg,抗-HBs,HBeAg,抗-HBe,抗-HBc).结果显示,C基因型感染者,非特异性CTL((19.91±6.01)%)高于B基因型感染者((16.12±3.12)%),t=3.05,P<0.01,HBVDNA水平((6.25±0.81)log10拷贝/mL)高于B基因型感染者((5.02±0.61)log10拷贝/mL),t=6.03,P<0.01,HBeAg阳性46例(74.19%),高于B基因型感染者(39例,占52%),χ2=7.09,P<0.01,丙氨酸氨基转移酶(ATL)、血清总胆红素(TBIL)水平(分别为(507.15±312.17)IU/L和(46.10±40.18)μmol/L)高于B基因型感染者(分别为(290.05±215.12)IU/L和(29.12±17.12)μmol/L),t=3.76,2.29,P<0.01,P<0.05.C基因型感染者的HBV特异性CTL((0.21±0.05)%),低于B基因型感染者((0.39±0.12)%),t=5.61,P<0.01.与CHB患者B基因型感染者相比,C基因型感染者的HBV特异性CTL较低,导致HBVDNA水平高于B基因型感染者,HBeAg阳性率也高于B基因型感染者,因此,C基因型感染者的肝功能损害比B基因型感染者重,另外,C基因型感染者的肝功能损害比B基因型感染者重,可能也与C基因型感染者的非特异性CTL比B基因型感染者高有关.
HBV genotyping was performed in 138 patients with CHB, and CTL, HBV-specific CTL, liver function, HBVDNA, HBVM (HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc) (19.91 ± 6.01)% were significantly higher than those infected with genotype B (16.12 ± 3.12%), t = 3.05, P <0.01, and the level of HBVDNA was (6.25 ± 0.81) mL) was higher than those infected with genotype B ((5.02 ± 0.61) log10 copies / mL), t = 6.03, P <0.01 and 46 patients with HBeAg positive (74.19% (507.15 ± 312.17) IU / L and (46.10 ± 40.18) μmol / L, respectively), χ2 = 7.09, P <0.01 and ATL and TBIL, L were significantly higher than those with genotype B (290.05 ± 215.12 IU / L and 29.12 ± 17.12 μmol / L, respectively), t = 3.76,2.29, P <0.01, Of HBV-specific CTL (0.21 ± 0.05)%, lower than genotype B (0.39 ± 0.12)%, t = 5.61, P <0.01.Compared with CHB patients infected with genotype B HBV genotype infected patients with low CTL, resulting in higher levels of HBVDNA than genotype B infection, HBeAg positive rate is also higher than genotype B infection, therefore, C genotype infected patients with liver damage than B Re-type infection, in addition, C genotype infected person’s liver damage heavier than genotype B infection, may be non-specific CTL C genotype infection related to higher than genotype B infection.