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质子泵抑制药(proton-pumm inhibitor,PPI)是一类能不可逆性抑制胃壁细胞质子泵(H~+-K~+-ATP酶)活性的药物,能使壁细胞内的H~+不能转运到胃腔中,阻断了胃酸分泌的最后步骤,使胃液中的胃酸量大为减少,对基础胃酸分泌和各种刺激因素引起的胃酸分泌均有很强的抑制作用。主要用于胃、十二指肠溃疡,反流性食管炎,卓-艾综合征,消化性溃
Proton-pumm inhibitor (PPI) is a class of drugs that can irreversibly inhibit the activity of proton pump (H ~ + -K ~ + -ATPase) in gastric parietal cells and can not transport H ~ + in parietal cells To the stomach cavity, blocking the last step of gastric acid secretion, so that gastric acid in gastric juice greatly reduced, the basis of gastric acid secretion and various stimuli caused by gastric acid secretion has a strong inhibitory effect. Mainly used for stomach, duodenal ulcer, reflux esophagitis, Zhuo - Ai syndrome, peptic ulcer