[Pritchard CC,et al.N Eng J Med,2016,375(5):443-453]前列腺癌作为欧美国家男性常见的恶性肿瘤,具有明显的遗传倾向。目前研究显示,DNA修复基因(如BRCA2)的突变与前列腺癌疾病进展和癌症相关致死率密切相关。然而,针对未发现家族易感性的局灶性前列腺癌患者,因DNA修复基因突变的水平极低,难以进行常规检测。而对于转移性前列腺癌患者,目前关于其DNA修复基因突变的频率鲜 [Pritchard CC, et al. N Eng J Med, 2016, 375 (5): 443-453] As a common malignant tumor in men in Europe and the United States, prostate cancer has a clear genetic predisposition. The current study shows that mutations in DNA repair genes (such as BRCA2) are closely related to the progression of prostate cancer and cancer-related lethality. However, for patients with focal prostate cancer who have not been found to have familial susceptibility, routine testing is difficult due to the extremely low levels of DNA repair gene mutations. For patients with metastatic prostate cancer, the current frequency of DNA repair gene mutations is low