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目的:探讨不同剂量米非司酮治疗围绝经期功血疗效。方法:92例围绝经期功血患者,随机分为对照组和观察组均46例,对照组予米非司酮12.5mg,1次/d,口服,观察组予米非司酮,6.25mg,1次/d,口服。结果:两组的E2、FSH、LH、P治疗后与治疗前组内比较,均显著下降(P<0.05),治疗后两组组间比较,观察组优于对照组(P<0.05);两组总有效率比较,未见显著差异(P>0.05)。两组不良反应比较,观察组少于对照组(P<0.05)。结论:小剂量米非司酮治疗围绝经期功血效果显著,不良反应小,安全可靠。
Objective: To investigate the effect of different doses of mifepristone on peri-menopausal dysfunctional uterine bleeding. Methods: A total of 92 patients with peri-menopausal dysfunctional uterine bleeding were randomly divided into control group and observation group, with 46 cases in the control group and 12.5 mg mifepristone, once a day. The patients in the observation group were given mifepristone, 6.25 mg , 1 time / d, orally. Results: The E2, FSH, LH and P in both groups were significantly decreased compared with those before treatment (P <0.05). After treatment, the observation group was better than the control group (P <0.05). The total effective rate between the two groups, no significant difference (P> 0.05). Two groups of adverse reactions, the observation group less than the control group (P <0.05). Conclusion: The low dose of mifepristone is effective in treating peri-menopause dysfunctional uterine bleeding, with less adverse reactions and safety.