白细胞介素12(IL-12)是近年新发现的一种细胞因子,主要来源于B淋巴细胞系。它是目前发现的细胞因子中唯一由异二聚体组成的因子,两亚基的分子量分别为40 kD和35 kD。两亚基的基因定位于不同的染色体上。IL-12具有多种生物学效应,只存在单一亲和力的膜受体。对IL-12的研究将有助于确定其在抗肿瘤和抗感染免疫中的重要作用。 Interleukin 12 (IL-12) is a newly discovered cytokine in recent years, mainly derived from B lymphocyte cell line. It is the only factor found in cytokines currently composed of heterodimers with molecular weights of 40 kD and 35 kD, respectively. Two subunits of the gene located in different chromosomes. IL-12 has a variety of biological effects, there is only a single affinity membrane receptor. Research on IL-12 will help determine its important role in anti-tumor and anti-infective immunity.