论文部分内容阅读
目的研究CD44S和CD44V6的表达与结肠癌临床病理特征之间的关系,以明确二者在结肠癌发展和预后中的作用。方法选取98例结肠癌组织做为实验组,采用免疫组织化学方法,检测组织中CD44S和CD44V6基因蛋白产物表达,与组织学分型、肠壁浸润深度、脉管有无浸润、淋巴结有无转移、预后等相关因素进行实验研究。结果 CD44S和CD44V6的表达与结肠癌组织类型无关,与癌组织浸润肠壁深度、脉管浸润、淋巴结转移、远处转移等密切相关。结论 CD44S和CD44V6异常表达可能参与了结肠癌的发展并可能影响患者的预后。
Objective To study the relationship between the expression of CD44S and CD44V6 and the clinicopathological features of colon cancer so as to clarify their roles in the development and prognosis of colon cancer. Methods Ninety-eight colon cancer tissues were selected as experimental group. The expression of CD44S and CD44V6 protein in tissues was detected by immunohistochemical method. The expressions of CD44S and CD44V6 protein in tissues were compared with histological type, depth of intestinal wall invasion, vascular invasion, lymph node metastasis, Prognosis and other related factors for experimental study. Results The expressions of CD44S and CD44V6 had no correlation with the type of colon cancer tissues, but were closely related to the depth of invasion, vascular invasion, lymph node metastasis and distant metastasis. Conclusion The abnormal expression of CD44S and CD44V6 may be involved in the development of colon cancer and may affect the prognosis of patients.