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目的探讨早期控制性降压对高血压脑出血患者短期病情恢复的影响。方法 2008-02-2009-08北京军区总医院263临床部神经内科收治高血压脑出血患者64例,随机分为对照组和治疗组,每组32例。治疗组与对照组基础治疗方法相同。治疗组于入院后即接受降压治疗,予以乌拉地尔、贝那普利、硝酸甘油、硝普钠等注射液单用或联用,使血压在入院后24 h内收缩压降至140 mm Hg。结果治疗后28 d两组NIHSS、MRS、Barthel指数评分比较差异有统计学意义(P<0.05)。治疗组平均住院37.6 d,对照组为51.8 d;治疗组住重症监护室天数6.3 d,对照组为11.6 d;住院费用治疗组为(10 013.8±628.2)元,对照组为(19 853.5±953.0)元。两组比较治疗组住院天数少,住院总费用低,差异均有统计学意义(P<0.05)。结论高血压脑出血患者早期降压可以缓解出血,对于改善预后,提高生活质量具有重要意义。
Objective To investigate the effect of early controlled hypotension on short-term recovery of patients with hypertensive intracerebral hemorrhage. Methods Sixty-four patients with hypertensive intracerebral hemorrhage admitted to Department of Neurology, Beijing Military Area General Hospital, Department of Neurology, Beijing Command of Chinese Medicine from February 2008 to February 2008 were randomly divided into control group and treatment group with 32 cases in each group. The treatment group and the control group the same basic treatment. The treatment group received antihypertensive treatment immediately after admission. Urapidil, benazepril, nitroglycerin, sodium nitroprusside and other injection alone or in combination, the systolic blood pressure dropped to 140 mm within 24 h after admission Hg. Results On the 28th day after treatment, NIHSS, MRS and Barthel index scores were significantly different between the two groups (P <0.05). The average length of hospital stay was 37.6 days in the treatment group and 51.8 days in the control group. The duration of intensive care unit stay in the treatment group was 6.3 days and that in the control group was 11.6 days. The treatment cost was 10 013.8 ± 628.2 yuan in the treatment group and 19 853.5 ± 953.0 in the control group )yuan. The two groups of treatment group less hospitalization days, the total cost of hospitalization was low, the difference was statistically significant (P <0.05). Conclusions Early treatment of hypertensive intracerebral hemorrhage can relieve hemorrhage in early stage, which is of great significance for improving prognosis and improving quality of life.