美国西雅图消息;过去十五年在欧洲,丙谷酰胺(Proglumide)作为抗溃疡药而畅销市场。现发现它是体内自然产生的鸦片阻断剂特别是胆囊收缩素[Cholecystokinin(CCK)]的有效拮抗剂。它可以增强吗啡的止痛作用。在这里举行的关于疼痛的世界会议上,加利福尼亚大学动物生理系神经生理学助教Linda R Watkins指出:因为CCK至少一部分与鸦片产生的耐受性有关,故服用丙谷酰胺和其他同CCK拮抗剂相似药,不仅使内科医生可以较小剂量和较少的次数使用鸦片素来控制 Seattle, USA news; Proglumide has been marketed as an antiulcer drug in Europe for the past 15 years. It is now found to be a potent antagonist of naturally occurring opiate blockers, especially cholecystokinin (CCK). It can enhance the analgesic effect of morphine. Linda R Watkins, assistant professor of neurophysiology at the Department of Veterinary Physiology, University of California, Los Angeles, said at the World Conference on Pain here that, because at least part of CCK is associated with opioid tolerance, propranamide and other drugs similar to CCK antagonists , Not only allows physicians to control opioids at smaller doses and fewer times