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本工作选用成年雄性Ｗｉｓｔａｒ大鼠，由平原（海拔５ｍ）直接运送到海拔２２６ｌｍ和３４６０ｍ高原现场。在２４小时急性习服期，以放射免疫测定法（ＲＩＡ），研究了大鼠脑垂体及各项区内β－内啡肽样免疫活性物质（ｉｒ－β－ＥＰＬＩ，β－ＥＰ）的含量变化结果表明，大鼠在高原２２６１ｍ和３４６０ｍ急性习服期，与平原者对照组相比，垂体内β－ＥＰ含量降低非常显著（Ｐ＜０．０１），纹状体、下丘脑、丘脑、桥延、皮层、海马内β－ＥＰ含量增加非常显著（均为Ｐ＜０．０１）。据此认为，哺乳动物急进高原低氧环境后在应激状态下，中枢内β－ＥＰ的合成与分泌受到明显影响。提示，脑内β－ＥＰ参与高原应激反应过程。
In this study, adult male Wistar rats were selected and transported directly from plains (elevation 5m) to the sites of 226lm and 3460m above sea level. The levels of β-endorphin-like immunoreactive substance (ir-β-EPLI, β-EP) in the pituitary gland and various regions of the rat were studied by radioimmunoassay (RIA) The results showed that there was a significant decrease in the content of β-EP in pituitary (P <0.01) in striatum, hypothalamus, hypothalamus, thalamus, The prolongation of β-EP in the cortex, cortex and hippocampus increased significantly (all P <0.01). Therefore, it is considered that the synthesis and secretion of β-EP in the central nervous system are significantly affected under the stress state after the mammals rapidly enter the plateau hypoxia environment. Tip, brain β-EP involved in high altitude stress response process.