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目的探讨影响重症中暑患者发生急性肝功能损害的相关危险因素。方法选取本院于2007年8月至2016年10月期间收治的40例重症中暑患者分为研究组(肝功能损害组)和对照组(无肝功能损害组)各20例,对其临床资料、治疗情况、实验室检查和辅助检查进行分析与比较。结果重症中暑患者发生急性肝功能损害与病程的长短、血钠、尿素氮、肌酸激酶及体温等因素有着密切的关系(P<0.05),而与血白细胞计数、血钾、肌酐、发病年龄无关(P>0.05)。患者入院时表现的最初体温是重症中暑患者急性肝功能损害产生的最危险且敏感的影响因素,其相对危险度达4.026;肌酸激酶水平和血钠含量排次之,分别为OR=1.984,OR=2.543。结论重症中暑患者发生急性肝功能损害与病程的长短、血钠、尿素氮、肌酸激酶及体温等影响因素有着密切的关系,同时与其预后也密切相关。因此,需要早期确诊和应用积极有效的治疗对危险因素进行防控,并进行合理的护养,提高疾病的治愈率。
Objective To investigate the related risk factors of acute liver dysfunction in patients with severe heat stroke. Methods Forty patients with severe stroke who were treated in our hospital from August 2007 to October 2016 were divided into two groups: study group (liver injury group) and control group (without liver injury group), and their clinical data , Treatment, laboratory tests and laboratory tests for analysis and comparison. Results There was a close relationship between the severity of acute liver injury and severity of disease, serum sodium, urea nitrogen, creatine kinase and body temperature in patients with severe heat stroke (P <0.05), but not with blood leukocyte count, serum potassium, creatinine, Not related (P> 0.05). The initial body temperature during admission was the most dangerous and sensitive factor for acute liver injury in critically stroke survivors, with a relative risk of 4.026. The creatine kinase level and serum sodium level were ranked as 1.984, OR = 2.543. Conclusion Severe heat stroke patients with acute liver damage and duration of the disease, serum sodium, urea nitrogen, creatine kinase and body temperature and other influencing factors are closely related, but also with its prognosis are also closely related. Therefore, the need for early diagnosis and application of active and effective treatment of risk factors for prevention and control, and reasonable care, improve the cure rate of the disease.